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Self-Reported Effectiveness and Safety of a PEGylated Formulation for the Standardized Buccal Delivery of Cannabis Extracts

Therapeutic use of cannabinoids, the main active ingredients of Cannabis sativa L., is often hindered by their limited bioavailability and undesirable psychoactivity. We conducted an observational study in December 2016 and another one in February 2018 to investigate respectively i) the effectiveness of TrokieĀ®, a standardized formulation containing PEGylated cannabis extracts, to deliver cannabinoids via buccal absorption and ii) its long-term safety.